• Azaphen (Pipofezine) 25mg 50 tablets

Expiration date: 08/2021 

Active substance: Pipofezine 

Pharmachologic effect:

Tricyclic antidepressants from the group of non-selective inhibitors of neuronal uptake of monoamines. It has timoanalepticheskoe and sedative effect.

The mechanism of antidepressant action is associated with non-selective inhibition of reverse neuronal serotonin and norepinephrine, which increases their concentration in the CNS. Almost does not have m-anticholinergic activity and does not affect the activity of MAO. It has no cardiotoxicity.



Quickly and completely absorbed from the gastrointestinal tract. Bioavailability - about 80%. Time to Cmax - 2 hours.

Distribution and metabolism

Binding to plasma proteins - 90%. It is metabolized in the liver to inactive metabolites.


T1 / 2 -. 16 hours is derived from the body mainly by the kidneys.


  • Depressive disorders of mild to moderate severity (including depression with chronic physical diseases).

Dosage and administration:

The starting dose for adults is 25-50 mg in 2 divided doses (morning and afternoon). With good tolerance dose gradually increased to 150-200 mg / day (3-4 hours, final reception bedtime), in some cases - to 400 mg / day. The optimal daily dose - 150-200 mg, the maximum daily dose - 400-500 mg. When the desired effect of moving to maintenance doses - 25-75 mg / day. Treatments - up to 1 year (at least 1-1.5 months).

Side effects:

CNS: headache, dizziness.

From the digestive system: nausea, vomiting.

Other: allergic reactions.


  • Severe hepatic and / or renal failure
  • Simultaneous reception of MAO inhibitors
  • pregnancy
  • Lactation (breastfeeding)
  • Hypersensitivity to the drug.

Precautions should be prescribed the drug in patients with chronic heart failure, myocardial infarction, ischemic heart disease, states after stroke, infectious diseases, diabetes, children.

Pregnancy and lactation:

The drug is contraindicated during pregnancy and lactation.

Special instructions:

During treatment, prohibited the use of alcohol.

Effects on ability to drive vehicles and management mechanisms

During the reception azafen patients is not recommended to perform work that requires a rapid response (to drive and perform other potentially dangerous activities).


In case of overdose may increase side effects.

Treatment: symptomatic therapy.

Drug Interactions:

With simultaneous use of anticoagulants Azafen enhances effects of ethanol, antihistamines and other drugs which depress the central nervous system.

In an application Azafen reduces the effectiveness of anti-epileptic drugs.

Conditions and terms:

List B. The drug should be stored in a dry, dark, place inaccessible to children at temperature not above 25 ° C. Term of validity - 5 years.

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Azaphen (Pipofezine) 25mg 50 tablets

  • $5.84