Histaminolytics

Histaminolytics

Nentski was opened Histamine in 1876. It is a biogenic compound produced in the body in the decarboxylation of amino acid histidine. Histamine can also be produced by microorganisms present in the respiratory tract (Branchamella catarhalis, Haemophilus parainfluenzae, Pseudomonas aeruginosa). It is a component of certain poisons and secrets, irritating.

Under normal conditions, histamine is stored in granules of mast cells and basophils bound, inactive state. Various pathological States (anaphylactic shock, burns, frostbite, hay fever, hives and other allergic diseases), as well as intake of some chemical substances liberator accompanied by the release of histamine from the depot. Liberatore histamine are, in particular, d-tubokurarin, morphine, Radiocontrast iodine-containing drugs, poliglyukin and other high-molecular compounds. When allergic reactions of pre-sensitized mast cells histamine is released together with generated mediators (leukotrienes and prostaglandins). Secretion of histamine is a consequence of the interaction of s3a and s5a component of complement with specific membrane receptors, or the result of binding to the antigen in fixed cells, IgE. The maximum concentration of histamine in the blood is recorded in 5 min after its release in reactions of immediate hypersensitivity, and then it rapidly diffuses into the surrounding tissue. Free histamine causes spasm of smooth muscles (including muscles of the bronchi), the expansion of capillaries, and hypotension. Due to the action of histamine stasis of blood in the capillaries and increased permeability of their walls is accompanied by swelling of the surrounding tissues. In connection with the reflex excitation of the adrenal medulla secretes epinephrine (narrowing of arterioles and tachycardia). Histamine stimulates the secretion of gastric juice.

Only 2-3% of histamine is excreted unchanged, the remaining part is metabolized with the participation of diaminoksidazy to imidazoluksusnoy acid.

In 1950-55. Ash and Schild hypothesized that the effect of histamine is mediated through at least two subtypes of receptors: H1 and H2. In recent years it has become apparent that histamine is not only a mediator of some pathophysiological States, but also functions as a neurotransmitter. In 1983, J.-M. Arrang et al. identified in the CNS of a new subtype histaminergic receptor — H3.

H1-, H2-, H3-receptor conformation and different tissue localization. Stimulation of histamine H1-receptors causes vasodilation, increased vascular permeability, bronchial smooth muscle spasm and bowel. The most characteristic for the excitation of H2 receptor is increasing the secretion of the gastric glands. H2-receptors are involved in the regulation of the functions of the heart, the smooth muscle tone of the uterus, intestines, blood vessels. Together with H1 - receptors are involved in allergic and immune responses. In the CNS presents all three types of histamine receptors: H1 - and H2-receptors are located on postsynaptic membranes, N3 - localized mainly presynaptic. The stimulation of H3 receptors inhibited the release of the nerve endings of a number of mediators, including histamine, inhibited the transfer of excitation in the sympathetic nervous system. Through them mediated by such functions as sleep/wakefulness, hormonal secretion, cardiovascular control, etc. Studies conducted in recent years give grounds to count on the possibility of establishing special funds, acting on H3-receptors, for the treatment of diseases of the Central nervous system, including stimulants of cognitive functions for the treatment of Alzheimer's disease and other senile dementias, psychoses, and epilepsy.

There are two groups of drugs affecting histaminergic transmission: gistaminolitiki (directly stimulate receptors or increase the content of free endogenous histamine) and gistaminolitiki. Last, interacting with the receptor, prevent the binding of histamine with them, or lower the level of free histamine in the body.



Aciloc (Ranitidine) 25mg/ml 2ml 10 vials

Aciloc (Ranitidine) 25mg/ml 2ml 10 vials

Expiration date: 03/2019 Dosage form:solution for intravenous and intramuscular injection, tabl..

$7.98

Aerius (Desloratadine)

Aerius (Desloratadine)

Expiration date: 05/2019 The composition and form of issue:Tablets, film-coated. 1 tablet ..

$15.58

Allegra (Fexofenadine)

Allegra (Fexofenadine)

Expiration date: 120mg - 11/2018 180mg - 01/2020 Action: antiallergic Compositio..

$15.58

Allergodil (Azelastine)

Allergodil (Azelastine)

Expiration date: 12/2019 Structure and Composition: Spray for nasal administration metered..

$13.63

Aviamarin (Dimenhydrinate)

Aviamarin (Dimenhydrinate)

Expiration date: 05/2019 Aviamarin - a remedy for motion sickness. Composition:Active ingr..

$3.89

Cetirizine

Cetirizine

Expiration date: 01/2020 Pharmacological action Cetirizine - competitive antagonist of his..

$3.89

Cetirizine Teva

Cetirizine Teva

Expiration date: 12/2019 Trade name: Cetirizine-Teva Pharmacological action: Antihistamine..

$5.84

Cetrine (Cetirizine)

Cetrine (Cetirizine)

Expiration date: 04/2019 The composition and form of issue:Tablets, film-coated. 1 tablet conta..

$5.84

Chloropyramine 20mg/ml 1ml 5 vials

Chloropyramine 20mg/ml 1ml 5 vials

Expiration date: 05/2021 The composition and form of issueHloropiramin solution for in/in and/m..

$5.84

Chloropyramine 25mg 20 tablets

Chloropyramine 25mg 20 tablets

Expiration date: 01/2020 ..

$3.89

Claritin (Loratadine)

Claritin (Loratadine)

Expiration date: 03/2020 Structure and Composition:5 ml syrup contains Loratadine 5 mgExci..

$5.84

Clarotadine (Loratadine) 10mg 7 tablets

Clarotadine (Loratadine) 10mg 7 tablets

Expiration date: 06/2021 The composition and form of issue:Tablets. 1 tablet contains:loratadin..

$3.89

CromoHEXAL (Cromoglicic acid)

CromoHEXAL (Cromoglicic acid)

Expiration date: drops - 03/2020 spray - 11/2019 The composition and form of issue:Ey..

$3.89

Desloratadine

Desloratadine

Expiration date: 08/2020 Dosage Form: tablet, film-coated Composition1 tablet coated ..

$8.76

Dezal (Desloratadine)

Dezal (Desloratadine)

Expiration date: tablets - 11/2018 solution - 12/2019 Action: antiallergic, anti..

$6.23

Diazolin (Mebhydrolin)

Diazolin (Mebhydrolin)

Expiration date: 03/2021 Composition1 tablet contains 100 mg mebhydrolinPackaging10 or&nbs..

$3.50

Dimedrol (Diphenhydramine)

Dimedrol (Diphenhydramine)

Expiration date: 11/2021 The composition and form of issue: 1 ml solution for injection co..

$19.47

Donormyl (Doxylamine) 15mg 30 tablets

Donormyl (Doxylamine) 15mg 30 tablets

Expiration date: 09/2019 Structure and Composition:Film-coated tablets. 1 tablet contains ..

$9.74

Dramina (Dimenhydrinate) 50mg 10 tablets

Dramina (Dimenhydrinate) 50mg 10 tablets

Expiration date: 04/2022 Structure and Composition:Tablets. 1 tablet contains 50 mg of dim..

$5.65

Eladon (Fenspiride)

Eladon (Fenspiride)

Expiration date: 30 tablets - 03/2019 60 tablets - 06/2018 Action:Anti-inflammatory, ..

$9.35

Elizey (Desloratadine)

Elizey (Desloratadine)

Expiration date: 07/2019 Action:anti-allergic, antipruritic, protivoekssoudativeComposition:des..

$5.84

Epistat (Fenspiride)

Epistat (Fenspiride)

Expiration date: syrup - 07/2019 tablets - 04/2020 Action: Anti-inflammatory, an..

$5.84

Erispirus (Fenspiride)

Erispirus (Fenspiride)

Expiration date: 04/2019 Action: Anti-inflammatory , anti provocation broncho-constricting..

$5.84

Eurespal (Fenspiride)

Eurespal (Fenspiride)

Expiration date: 01/2020 The composition and form of issue:1 tablet coated liner contains fensp..

$7.79

Ezlor (Desloratadine) 5mg 10 tablets

Ezlor (Desloratadine) 5mg 10 tablets

Expiration date: 06/2020 Action: antiseptic , antipruritic, protivoekssoudativeComposition..

$9.74

Famotidine

Famotidine

Expiration date: 03/2020 Action:inhibits the production of hydrochloric acid, reduces the activ..

$2.92

Fenistil (Dimetindene)

Fenistil (Dimetindene)

Expiration date: 01/2020 International name: Dimetindene (Dimetindene)Group affiliation:H1..

$10.71

Fexadin (Fexofenadine)

Fexadin (Fexofenadine)

Expiration date: 03/2019 The composition and form of issue: Tablets, film-coated. 1 tablet..

$8.76

Fexofast (Fexofenadine) 180mg 10 tablets

Fexofast (Fexofenadine) 180mg 10 tablets

Expiration date: 01/2020 Action: anti-allergic Composition:Fexofenadine 180 mgExcipie..

$9.74

Glencet (Levocetirizine)

Glencet (Levocetirizine)

Expiration date: 08/2019 Clinico-pharmacological group(Blocker of histamine H1 receptors. Aller..

$8.37

Histafen (Sequifenadine) 50mg 20 tablets

Histafen (Sequifenadine) 50mg 20 tablets

Expiration date: 02/2021 Structure and Composition: Tablets. Active substance (oer 1 table..

$19.47

Intal (Cromoglicic acid) 5mg/dose 112 doses

Intal (Cromoglicic acid) 5mg/dose 112 doses

Expiration date: 02/2019 The composition and form of issue: 1 dose of aerosol inhalations ..

$20.83

Kestine (Ebastine)

Kestine (Ebastine)

Expiration date: 02/2020 Structure and Composition:Tablets, film-coated. 1 tablet contains ..

$6.23

Ketotifen Sopharma

Ketotifen Sopharma

Expiration date: 09/2019 Action: anti-allergicComposition:Syrup:the sour ketotifen fumarat..

$4.87

Klaridol (Loratadine)

Klaridol (Loratadine)

Expiration date: 11/2018 Structure and Composition:1 tablet contains loratadine 10 mg and excip..

$4.09

Klarisens (Loratadine)

Klarisens (Loratadine)

Expiration date: 06/2020 Structure and Composition:5 ml of syrup contains 5 mg loratadine, in d..

$3.60

Letizen (Cetirizine)

Letizen (Cetirizine)

Expiration date: 06/2020 Structure and Composition:1 tablet, film-coated, containing 10 mg of c..

$4.09

Levocetirizine

Levocetirizine

Expiration date: 05/2019 Release form, composition and packing7 pcs. - Blisters of aluminum foi..

$5.84

Lomilan (Loratadine)

Lomilan (Loratadine)

Expiration date: tablets - 03/2020 suspension - 11/2018 Structure and Composition:Tab..

$4.87

LoraHEXAL (Loratadine) 10mg 10 tablets

LoraHEXAL (Loratadine) 10mg 10 tablets

Expiration date: 03/2019 Structure and Composition:Tablets. 1 tablet contains active subst..

$3.12

Loratadine

Loratadine

Expiration date: 01/2021 Composition1 tablet contains active substance: loratadine 10 mgPharmac..

$3.89

Loratadine Akrihin

Loratadine Akrihin

Expiration date: 03/2022 TABLETS:Composition1 tablet contains active substance: loratadine 10 m..

$3.89

Loratadine Stada 10mg 10 tablets

Loratadine Stada 10mg 10 tablets

Expiration date: 02/2020 Composition1 tablet contains active substance: loratadine 10 mgPharmac..

$3.89

Loratadine Teva

Loratadine Teva

Expiration date: 09/2019 Composition1 tablet contains active substance: loratadine 10 mgPharmac..

$5.84

Lordestin (Desloratadine) 0.5ml/ml 60ml syrup

Lordestin (Desloratadine) 0.5ml/ml 60ml syrup

Expiration date: 10/2018 Release form, composition and packagingSyrup transparent, colorless, w..

$7.79

Lordestin (Desloratadine) tablets

Lordestin (Desloratadine) tablets

Expiration date: 10 tablets - 05/2021 30 tablets - 10/2018 The composition and form o..

$9.74

Migrenol PM (Diphenhydramine + Paracetamol)

Migrenol PM (Diphenhydramine + Paracetamol)

Expiration date: 11/2018 Action: analgesic antihistamines, sedativesComposition:paracetamo..

$5.84

Momate Rhino Advance (Azelastine+Mometasone) 150 doses spray nasal

Momate Rhino Advance (Azelastine+Mometasone) 150 doses spray nasal

Expiration date: 10/2018 Dosage formWhite or almost white suspensionComposition1 dose of s..

$13.63

Nalorius (Desloratadine) 5mg 10 tablets

Nalorius (Desloratadine) 5mg 10 tablets

Expiration date: 03/2021 ..

$5.84

Nixar (Bilastine)

Nixar (Bilastine)

Expiration date: 09/2021 ..

$8.76

Ocumethyl (Diphenhydramine + Naphazoline + Zinc sulfate) 10ml eye drops

Ocumethyl (Diphenhydramine + Naphazoline + Zinc sulfate) 10ml eye drops

Expiration date: 07/2019 Composition Diphenhydramine hydrochloride, naphazoline hydrochlor..

$7.20

Parlazin (Cetirizine)

Parlazin (Cetirizine)

Expiration date: drops - 01/2021 tablets - 01/2020 The composition and form of issue:..

$5.84

Phencarol (Hifenadin)

Phencarol (Hifenadin)

Expiration date: 01/2022 The composition and form of issue:Tablets. 1 tablet contains active su..

$7.79

Polynadim (Diphenhydramine + Naphazoline) 10ml eye drops

Polynadim (Diphenhydramine + Naphazoline) 10ml eye drops

Expiration date: 05/2020 Release form and composition: Eye drops in the form of a clear, s..

$3.89

Psilo-balsam (Diphenhydramine) 20g gel

Psilo-balsam (Diphenhydramine) 20g gel

Expiration date: 06/2020 The composition and form of issue: Gel for external use, 100..

$7.79

Quamatel (Famotidine)

Quamatel (Famotidine)

Expiration date: vials - 07/2019 tablets - 01/2021 The composition and form of issue:..

$5.84

Ranisan (Ranitidine) 150mg 20 tablets

Ranisan (Ranitidine) 150mg 20 tablets

Expiration date: 06/2019 The composition and form of issue: Tablets, film-coated. 1 tablet..

$3.12

Ranitidine

Ranitidine

Expiration date: 06/2020 The composition and form of issue: Tablets, film-coated. 1 t..

$2.43

Resleep (Doxylamine) 15mg 30 tablets

Resleep (Doxylamine) 15mg 30 tablets

Expiration date: 04/2019 the action: A blocker of histamine H1-receptors from the group of..

$7.79

Rinicold Broncho 100ml syrup

Rinicold Broncho 100ml syrup

Expiration date: 10/2019 Release form and composition: The thick syrup, from light orange ..

$5.84

Rinzasip with Vitamin C

Rinzasip with Vitamin C

Expiration date: 10/2019 Release form and composition: Powder for preparation of oral..

$6.43

Rupafin (Rupatadine)

Rupafin (Rupatadine)

Expiration date: 04/2020 Clinico-pharmacological group (The blocker of histamine H1-recept..

$9.74

Siel (Dimenhydrinate) 50mg 5 tablets

Siel (Dimenhydrinate) 50mg 5 tablets

Expiration date: 05/2019 The composition and form of issue: Tablets. 1 tablet contains:dim..

$4.87

Siresp (Fenspiride) 2mg/ml 150ml syrup

Siresp (Fenspiride) 2mg/ml 150ml syrup

Expiration date: 06/2020 Action: Expectorant, anti-inflammatory, secre - and bronchodilato..

$7.79

Suprastin (Chloropyramine)

Suprastin (Chloropyramine)

Expiration date: 12/2021 Structure and Composition: Tablets. One tablet contains ..

$4.67

Suprastinex (Levocetirizine)

Suprastinex (Levocetirizine)

Expiration date: 12/2021 The composition and form of issue: Tablets, film-coated. 1 t..

$7.79

Tavegyl (Clemastin)

Tavegyl (Clemastin)

Expiration date: 02/2020 Release form pills Composition1 tablet contains 1 mg clemast..

$5.84

Tavegyl (Clemastin) 1mg/ml 2ml 5 vials

Tavegyl (Clemastin) 1mg/ml 2ml 5 vials

Expiration date: 12/2021 The composition and form of issue: 1 tablet contains clemast..

$7.79

Tilade Mint (Nedocromil sodium) 2mg/dose 112 doses aerosol

Tilade Mint (Nedocromil sodium) 2mg/dose 112 doses aerosol

Expiration date: 06/2019 The composition and form of issue: 1 dose aerosol contains sodium..

$71.26

Valocordin-Doxylamine 25mg/ml 20ml

Valocordin-Doxylamine 25mg/ml 20ml

Expiration date: 07/2021 Release Form: Drops for oral administration Composition..

$7.40

Vibrocil (Dimethindene + Phenylephrine) 15ml drops nasal

Vibrocil (Dimethindene + Phenylephrine) 15ml drops nasal

Expiration date: 04/2020 The composition and form of issue: 1 ml of nasal drops or spray a..

$8.76

Xyzal (Levocetirizine)

Xyzal (Levocetirizine)

Expiration date: 10/2020 Structure and Composition: Tablets, film-coated. 1 tablet co..

$8.76

Zaditen (Ketotifen) 0.25mg/ml 5ml eye drops

Zaditen (Ketotifen) 0.25mg/ml 5ml eye drops

Expiration date: 01/2018 Release form and composition: Eye drops, 1 ml contains:the ketoti..

$13.43

Zantac (Ranitidine) 25mg/ml 2ml 5 vials

Zantac (Ranitidine) 25mg/ml 2ml 5 vials

Expiration date: 05/2018 The composition and form of issue: Solution for injection. 1 ml c..

$6.43

Zodac (Cetirizine)

Zodac (Cetirizine)

Expiration date: 05/2020 Description pharmaceutical form: Tablets: oblong, film-coated whi..

$4.87

Zyrtec (Cetirizine)

Zyrtec (Cetirizine)

Expiration date: 10/2021 Structure and Composition: Tablets, film-coated. 1 tablet co..

$6.81

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