Expiration date: 01/2020 

The composition and form of issue:

The intravenous solution 1 ampoule or 1 vial contains active substance: 

Panavir (purified extract of plant shoots Solanum tuberosum, the main active ingredient — exony glycoside consisting of glucose, ramnose, arabinose, mannose, xylose, galactose, uronic acid) 0,2 mg / 1 amp. or 1 FL.

excipients: 0.9% sodium chloride solution 

R-R for I/V administration of 0.04 mg/ml in ampoules or vials of 5 ml solution for I/V administration of 0.1 mg/ml in ampoules or vials of 2 ml solution for I/V administration of 0.2 mg/ml in ampoules or vials of 1 ml

2 or 5 or 10 ampoules or vials in a contour acheikova packing in cartons of 1 or 2 the contour of the package with a knife ampulnam or scarifier ceramic.

Gel for external and local use 1 tube contains active substance: 

Panavir (purified extract of plant shoots Solanum tuberosum, the main active ingredient — exony glycoside consisting of glucose, ramnose, arabinose, mannose, xylose, galactose, uronic acids) 0.002 g per 100 g

excipients: glycerol, polyethylene oxide 400, 4000 polyethylene oxide ethyl alcohol sodium hydroxide of lanthanum nitrate, distilled water 

in tubes of aluminum or plastic for 3 and 30 g in a cardboard bundle 1 tuba.

Rectal suppositories 1 suppositoris contains active substance: 

Panavir (purified extract of plant shoots Solanum tuberosum, the main active ingredient — exony glycoside consisting of glucose, ramnose, arabinose, mannose, xylose, galactose, uronic acids) 200 mg

excipients: suppository mass of 1.2 g — solid confectionery fat based on plasticized hydrogenated fat or solid fat is 80-90% paraffin 5-10% emulsifier T-2 — 5-10% 

in a contour acheikova package 5 PCs. in cardboard pack 1 pack.

Description pharmaceutical form:

Solution for the on/in the introduction transparent, colorless liquid, odorless, salty taste.

Gel for external and local application: a homogeneous mass of white color with a weak specific smell.

Rectal suppositories: white with yellowish tint with a specific smell, a conical or cylindrical shape is allowed yellowish-grey patches, with a specific smell.

Pharmacokinetics:

The solution for the on/in the introduction: when in/in the introduction polysaccharides are found in the blood within 5 min after administration, are captured by cells of the reticulo-endothelial system of the liver and spleen. The excretion begins rapidly, within 20-30 min the polysaccharides found in the urine and exhaled air.

Description pharmacological action:

Panavir(Panavir) is a high molecular polysaccharide belonging to the class hexonic glycosides.

The drug Panavir is an antiviral and immunomodulatory agent. Increases nonspecific resistance to various infections and contributes to the induction of interferon.

In therapeutic doses the drug is well tolerated.

Tests showed the absence of mutagenic, teratogenic, carcinogenic, allergenic and embryotoxic action.

In experimental studies, adverse effects on reproduction and fetal development was not established. Has anti-inflammatory properties in experimental models of exudative edema, chronic proliferative inflammation in test allergic inflammatory response to A. concanavalin

Shows analgesic effect in models of neurogenic pain and pain caused by inflammatory process. The duration of the increase of pain thresholds in thermal irritation is a positive dose-dependent nature.

It has antipyretic action.

Has wound healing properties in animal model of gastric ulcer.

Indications:

Solution for I/V administration and rectal suppositories:

  • herpes infections of different localization (including recurrent genital herpes, herpes Zoster and ophthalmic herpes)
  • secondary immunodeficiency on the background of infectious diseases
  • cytomegalovirus infection, including in patients with habitual miscarriage of pregnancy
  • can be used in women with chronic viral infection and interferonogenami condition at the stage of preparation for pregnancy
  • human papillomavirus infection (anogenital warts) in the treatment of
  • complex therapy of gastric ulcer and duodenal ulcer in patients with long-term scarring ulcers and symptomatic ulcers of astroduodenal zone
  • treatment of tick-borne encephalitis to reduce the viral load and relieve neurological symptoms (entrelace, decreased reflexes, pain exit points of cranial nerves, nystagmus) in the treatment of
  • comprehensive treatment of immunocompromised patients increases with rheumatoid arthritis to enhance the analgesic and anti-inflammatory effect of concomitant therapy with the herpes simplex virus.

Solution for the on/in the introduction (optional):

  • complex therapy of ARVI and flu
  • complex therapy of chronic bacterial prostatitis.

Gel for external and local application:

  • infectious-inflammatory diseases of the skin caused by the herpes simplex virus Herpes simplex types I and II (including genital herpes) and Herpes Zoster (shingles)
  • human papillomavirus infection (applied to the destruction of places of papillomas to complete healing) — in combination therapy.

Contraindications:

Solution for I/V administration and rectal suppositories:

  • idiosyncrasy
  • the presence of Allergy to components of the preparation: glucose, mannose, rhamnose, lactose, arabinose, xylose
  • severe renal pathology and spleen
  • children up to age 12 years.

Solution for the on/in the introduction (optional):

  • lactation.

Gel for external and local application:

  • the presence of Allergy to components of the preparation: glucose, mannose, rhamnose, lactose, arabinose, xylose.

Application of pregnancy and breast-feeding:

Solution for I/V administration and rectal suppositories: use during pregnancy is possible only in the case when expected benefit for mother and fetus outweighs the potential risk of adverse events. If necessary, use of the drug during lactation should stop breastfeeding.

Side effects:

Solution for I/V administration and rectal suppositories: the drug is well tolerated, possible complications can be associated with individual intolerance and hypersensitivity to the components of the preparation.

However, if you experience any unwanted side effects should stop the drug and consult with your doctor.

Gel for external and local application: there may be quickly passing redness and itching of the skin or mucosa at the site of gel.

Drug interactions:

It is not revealed.

Method of application and dose:

Solution for I/V administration: in/in struino slowly — 200 mcg (contents of 1 amp.).

Panavir in the solution used for I/V injection of a therapeutic dose of 200 mcg (contents of one ampoule or vial) active substance. For treatment of herpes infections and tick-borne encephalitis Panavir is used twice with an interval of 48 or 24 hours If necessary, after a month treatment can be repeated. For the treatment of cytomegalovirus and human papillomavirus infection Panavir is used three times in the first week with an interval of 48 h and twice in the second week with an interval of 72 h. For the treatment of gastric ulcer and duodenal ulcer in acute phase and symptomatic ulcers of the gastroduodenal zone used 5 in/in injections a day for 10 days.

When the herpes simplex virus in patients with rheumatoid arthritis — 5 injections with an interval of 24-48 hours, if necessary repeat the course after 2 months. For the treatment of patients with SARS and influenza, use 2 intravenous injection with an interval of 18-24 hours.

Panavir should enter the jet slowly.

Gel for external and local application: apply a thin layer on the affected skin or mucosa without rubbing 5 times a day. Duration of treatment — 4-5 days. The treatment can be extended to 10 days.

Vaginally. A small amount of gel administered vaginally and spread it evenly in a thin layer on the vaginal wall. Treatment continued until complete disappearance of clinical manifestations.

Rectal suppositories: rectally, the dosage regimen is similar to the mode of dosing solution for the on/in the introduction (ratio 1 supp. — 1 amp.).

Use in Pediatrics

Panavir administered to children from 12 years at a dose of 100 mcg (half content 1 amp.), in/in struino slowly.

Overdose:

The solution for the on/in the introduction: in case of overdose possible reversible disruption of the functions of the kidneys and spleen.

Rectal suppositories: overdose is unlikely. Possible reversible disruption of the functions of the kidneys and spleen.

Special instructions:

The solution for the on/in the introduction: if you are using at the stage of preparation for pregnancy decreases the frequency of reproductive losses in cytomegalovirus and herpes virus infections.

If clouding of the solution of the drug is considered to be unusable.

Gel for external and local application: it is recommended to start treatment in the early stage of the disease at the first signs (itching, tingling, redness, feeling of tension), in this case, the development of the bubble stage of the disease can be completely prevented.

Panavir gel can not be used in ophthalmology. When applying the gel on the face and avoid its contact with eyes.

Review:

Full information about the drug on the website www.panavir.ru.

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Panavir


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