• Tienam (Imipenem + Cilastatin) 500mg + 500mg 10 vials

Expiration date: 01/2019 

The composition and form of issue 

1 bottle of 5 ml with sterile powder for preparation of solution for I/V injection contains imipenem 500 mg, and cilastatin sodium 500 mg; in a box 10 bottles.

Pharmacological action

Pharmacological action — anti-bacterial, antibacterial, antimicrobial.

Imipenem inhibits cell wall synthesis of bacteria cilastatin inhibits the biotransformation imipenem in the kidney and increases its concentration in the urinary tract.

Clinical pharmacology

It has a bactericidal effect on a wide range of gram-positive and gram-negative aerobic and anaerobic microorganisms. Not indicated for the treatment of meningitis. Patients with Cl creatinine 5 ml/min/1.73 m2 and less can be assigned, if every 48 hours hemodialysis is carried out.

The testimony of the drug Tienam

Intraperitoneal infections, infections of the lower respiratory tract, genitourinary system, bones and joints, skin and soft tissues; septicemia; endocarditis; prevention of postoperative infections; mixed infections.


Hypersensitivity (including to other beta-lactams — penicillins, cephalosporins), children's age (up to 3 months).

Application during pregnancy and breast-feeding

During pregnancy, appointed exclusively for life reasons. In appointing nursing mothers breast-feeding should be suspended.

Side effect

Dyspepsia, change of quantitative content of formed elements of blood, increased liver enzymes; oliguria, anuria, polyuria, acute renal failure; seizures, myoclonia, mental impairment and confusion; disturbance of taste, local reactions (erythema, pain and infiltration at the injection site, thrombophlebitis), pseudomembranous colitis, allergic reactions (itching, hives, fever, anaphylactic shock, etc.).


Pharmacologically incompatible with other antibiotics. In the presence of lactic acid inactivated.

Method of application and doses

In/m and/in / in / in the form of infusion: ≤500 mg - for 20-30 minutes,>500 mg-40-60 minutes. the Average daily dose-2000 mg (4 injections). The maximum daily dose-4000 mg (50 mg/kg). The dose is adjusted for the severity of the condition, body weight and kidney function of the patient.

For the prevention of postoperative infections in adults, I/b-1000 mg with an introductory anesthesia and 1000 mg after 3 hours With a very high risk of postoperative infection for another 500 mg / b 8 and 16 hours after anesthesia. Children: weighing less than 40 kg and with sepsis, and 15 mg/kg every 6 hours (but not more than 2000 mg/day).

In / m, adults-500 or 750 mg every 12 hours (up to 1500 mg/day).

Precautionary measures

Be wary appoint patients with diseases of the gastrointestinal tract in the anamnesis (especially colitis). / M forms of the drug should not be used for on/in the introduction, and / in — for / m.

Special instruction

Do not administer in the same syringe with other antibiotics. Do not use as a solvent solutions containing lactate.

Storage conditions of the drug Tienam

At a temperature not exceeding 25 °C.

Keep out of reach of children.

The shelf life of the drug Tienam

powder for preparing a solution for intramuscular administration 500 mg + 500 mg 500 mg + 500-3 years.

powder for solution for infusion 500 mg + 500 mg 500 mg + 500-2 years.

powder for solution for infusion 500 mg + 500 mg 500 mg + 500-2 years.

Do not use after the expiry date indicated on the package.

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Tienam (Imipenem + Cilastatin) 500mg + 500mg 10 vials

  • $233.64